Marc Degryse was born in the West Flemish city of Roeselare and started his carreer at VC Ardooie. Club Brugge noticed his talent and offered him a contract in 1984. In 1990, the midfielder left to Brussels, to play for Anderlecht. He won four titles in six seasons and played 171 games in which he scored 67 goals.

After twelve years in Belgium, Degryse was transfered to Sheffield Wednesday in the Premier League. He only stayed there for one season and in the summer of 1996, he moved to PSV Eindhoven. Two years later, he returned to Belgium to end his carreer. He went to AA Gent first, but played his last game for Germinal Beerschot against Charleroi (4-1 victory). The date was May 4 of the year 2002.

On September 5 of the year 1984, he made his debute for the Belgian national team in the game against Argentina. In his last international game, he lost with Belgium against Holland (0-3) on December 14 1996. By then, he had played 63 games and scored 23 goals.