Vincenzo Scifo, a Belgian with Italian roots, joined the local club La Louvière when he was 7 years old. Being 14, he made his debute for the first team. He was soon discovered by Anderlecht and made his debute at the age of 17. The year is 1983 and it would take two more years before his first selection for the national team. Scifo would win three successive titles with Anderlecht.

Because of his good performance, several foreign teams showed interest in Scifo. He makes to move to Inter Milan and leaves one year later for Girondins de Bordeaux, where he ends up on the bench.

Guy Roux and AJ Auxerre saved Scifo's carreer. He spends two good years playing for the French club. Then he moves back to Italy where he played for Torino FC. Scifo ends third in the Italian league and loses the final of the UEFA Cup against Ajax, after eliminating Real Madrid in the semi finals ('91-'92). The next season, Torino ends 9th, but wins the Coppa Italia.

Scifo then returns to France, to AS Monaco. In '93-'94, the club reaches the semi finals of the Champions League and is being eliminated by AC Milan. In 1997, the club wins the French title and loses in the semi finals of the UEFA Cup against Inter Milan. Scifo played for Monaco during 4 years and won one title.

Scifo then returns to RSC Anderlecht. In 2000, he wins a new title and ends his professional carreer for Charleroi, before becoming trainer of the second division team Tubize.

Scifo played 84 games for the national team and participated on four World Cups (1986, 1990, 1994 and 1998). In 1984, Enzo wins the Golden Shoe and on the World Cup in Italy, he's being elected as second best player of the tournament, after Lothar Matthäus.